Hydrochloric Acid → HCID 178432717, compound

Participants

Reaction Steps

To a solution of 2-methyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-thiazole (2.72 g) in methanol (30 mL) was added concentrated hydrochloric acid (1.00 mL) at room temperature, and the mixture was stirred at room temperature for 18 hrs. The reaction mixture was evaporated under reduced pressure, and the residue was washed with ethyl acetate-methanol to give 4-[(E)-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-ol.hydrochloride (2.30 g, yield 90%) as pale-yellow crystals. melting point: 211-212° C.

Provenance & Evidence