Hydrochloric Acid → HCID 178432717, compound

HRID 2221683Notes

Reaction equation

HRID 2221683 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5](/[CH:7]=[CH:8]/[C:9]2[C:10]([O:20]COC)=[N:11][N:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:13]=2)[N:6]=1.[ClH:24]>CO>[ClH:24].[CH3:1][C:2]1[S:3][CH:4]=[C:5](/[CH:7]=[CH:8]/[C:9]2[C:10]([OH:20])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:13]=2)[N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 230766172-methyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-thiazole

Product 1

HCID 178432717HCID 178432717, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-thiazole (2.72 g) in methanol (30 mL) was added concentrated hydrochloric acid (1.00 mL) at room temperature, and the mixture was stirred at room temperature for 18 hrs. The reaction mixture was evaporated under reduced pressure, and the residue was washed with ethyl acetate-methanol to give 4-[(E)-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-ol.hydrochloride (2.30 g, yield 90%) as pale-yellow crystals. melting point: 211-212° C.

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate-methanol

Sources & evidence

ORD record
ord-1b5322b0862d477896366b8dcd616bd4
Source dataset
uspto-grants-2008_05
Patent number
US07368578B2

Reaction notes

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