反应详情

To a solution of 2-methyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-thiazole (2.72 g) in methanol (30 mL) was added concentrated hydrochloric acid (1.00 mL) at room temperature, and the mixture was stirred at room temperature for 18 hrs. The reaction mixture was evaporated under reduced pressure, and the residue was washed with ethyl acetate-methanol to give 4-[(E)-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-ol.hydrochloride (2.30 g, yield 90%) as pale-yellow crystals. melting point: 211-212° C.

1. customThe reaction mixture was evaporated under reduced pressure
2. washthe residue was washed with ethyl acetate-methanol