反应详情

To a solution of 2-tert-butyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-thiazole (2.4 g) in methanol (30 mL) was added concentrated hydrochloric acid (0.8 mL) at room temperature, and the mixture was stirred at room temperature for 24 hr. The reaction mixture was evaporated under reduced pressure, and the residue was washed with ethyl acetate-hexane to give 4-[(E)-2-(2-tert-butyl-1,3-thiazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-ol.hydrochloride (2.1 g, yield 91%) as pale-yellow crystals. melting point: 209-211° C.

1. customThe reaction mixture was evaporated under reduced pressure
2. washthe residue was washed with ethyl acetate-hexane