反应详情

温度

50 °C

To a solution of 1-(4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-5-methyl-1,3-thiazol-2-yl)piperidine (0.61 g) in methanol (30 mL) was added concentrated hydrochloric acid (0.3 mL) at room temperature, and the mixture was stirred at 50° C. for 1 hr. The reaction mixture was evaporated under reduced pressure, and the residue was washed with ethyl acetate-methanol to give 4-({E}-2-[5-methyl-2-(piperidin-1-yl)-1,3-thiazol-4-yl]ethenyl)-1-phenyl-1H-pyrazol-3-ol.hydrochloride (0.49 g, yield 81%) as yellow prism crystals. melting point: 224-226° C.

1. customThe reaction mixture was evaporated under reduced pressure
2. washthe residue was washed with ethyl acetate-methanol