反应详情

温度

50 °C

To a solution of 4-(4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-5-methyl-1,3-thiazol-2-yl)morpholine (1.0 g) in methanol (20 mL) was added concentrated hydrochloric acid (0.4 mL) at room temperature, and stirred at 50° C. for 1.5 hrs. The reaction mixture was evaporated under reduced pressure, and the residue was washed with ethyl acetate-methanol to give 4-{(E)-2-[5-methyl-2-(morpholin-4-yl)-1,3-thiazol-4-yl]ethenyl}-1-phenyl-1H-pyrazol-3-ol.hydrochloride (0.98 g, yield 100%) as gray crystals. melting point: 278-279° C.

1. customThe reaction mixture was evaporated under reduced pressure
2. washthe residue was washed with ethyl acetate-methanol