Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2221754생성일: 2026년 10월 26일
Dimethylformamide → ethyl 1-benzyl-3-[(6-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-pyridinyl)methoxy]-1H-pyrazole-4-carboxylate
https://huagongshe.com/reaction/2221754
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Chloromethyl-2-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]pyridine | HCID 23076379 | — |
| 반응물 | HCID 178469738 | HCID 178469738 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | ethyl 1-benzyl-3-[(6-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-pyridinyl)methoxy]-1H-pyrazole-4-carboxylate | HCID 69218263 | 91.1% |
반응 단계
A mixture of 5-chloromethyl-2-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}pyridine (1.30 g), ethyl 1-benzyl-3-hydroxy-1H-pyrazole-4-carboxylate (1.06 g), potassium carbonate (0.59 g) and N,N-dimethylformamide (50 mL) was stirred at 90° C. for 2 hrs. Water was poured into the reaction mixture, and the precipitated crystals were collected by filtration to give ethyl 1-benzyl-3-[(6-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-pyridinyl)methoxy]-1H-pyrazole-4-carboxylate as colorless crystals (2.00 g, yield 90%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 140-141° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07368578B2 |
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| 출처 데이터셋 | uspto-grants-2008_05 |
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| ORD ID | ord-643568c240a945c6b44e7a8a54b358c1 |
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| 출처 메모 | uspto-grants-2008_05 |
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