反应详情

温度

90 °C

A mixture of 5-chloromethyl-2-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}pyridine (1.30 g), ethyl 1-benzyl-3-hydroxy-1H-pyrazole-4-carboxylate (1.06 g), potassium carbonate (0.59 g) and N,N-dimethylformamide (50 mL) was stirred at 90° C. for 2 hrs. Water was poured into the reaction mixture, and the precipitated crystals were collected by filtration to give ethyl 1-benzyl-3-[(6-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-pyridinyl)methoxy]-1H-pyrazole-4-carboxylate as colorless crystals (2.00 g, yield 90%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 140-141° C.

1. filtrationthe precipitated crystals were collected by filtration