反应详情

A mixture of (3-{[3-methoxy-4-(5-methyl-2-phenyl-1,3-oxazol-4-ylmethoxy)benzyl]oxy}-1-methyl-1H-pyrazol-4-yl)methanol (3.40 g), activated manganese dioxide (10.03 g) and tetrahydrofuran (50 mL) was stirred overnight at room temperature. Manganese dioxide was removed by filtration, and the filtrate was concentrated to give 3-{[3-methoxy-4-(5-methyl-2-phenyl-1,3-oxazol-4-ylmethoxy)benzyl]oxy}-1-methyl-1H-pyrazole-4-carbaldehyde (3.25 g, yield 96%) as colorless crystals. The crystals were recrystallized from acetone-hexane. melting point: 123-124° C.

1. customManganese dioxide was removed by filtration
2. concentrationthe filtrate was concentrated