反应详情

A mixture of [5-({4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenoxy}methyl)-2-phenyl-1,3-oxazol-4-yl]methanol (3.10 g), activated manganese dioxide (10.0 g) and tetrahydrofuran (300 mL) was stirred at room temperature for 15 hrs. Manganese dioxide was removed by filtration, and the filtrate was concentrated. The obtained crystals were collected by filtration and washed with hexane to give 5-({4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenoxy}methyl)-2-phenyl-1,3-oxazole-4-carbaldehyde (2.75 g, yield 89%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 127-128° C.

1. customManganese dioxide was removed by filtration
2. concentrationthe filtrate was concentrated
3. filtrationThe obtained crystals were collected by filtration
4. washwashed with hexane