Bromotrimethylsilane → HCID 22349213, compound

HRID 2222117Notes

Reaction equation

[Cl:1][C:2]1[S:3][C:4]([CH2:8][O:9][CH2:10][P:11]([O:16]CC)([O:13]CC)=[O:12])=[C:5]([Cl:7])[N:6]=1.C[Si](Br)(C)C>>[Cl:1][C:2]1[S:3][C:4]([CH2:8][O:9][CH2:10][P:11]([OH:13])([OH:16])=[O:12])=[C:5]([Cl:7])[N:6]=1

Participants

Reactant 2

HCID 76113Bromotrimethylsilane

HCID 574577912,4-Dichloro-5-(diethylphosphonomethoxymethyl)thiazole

Product 1

HCID 22349213HCID 22349213, compound

Procedure

2,4-Dichloro-5-(diethylphosphonomethoxymethyl)thiazole was deesterified with TMSBr as described in Step D, Example 1, to provide the title compound (no. 14.01) as a solid. HPLC Rt=4.36 min; negative ion electrospray MS M-1 found: 276/278.

Sources & evidence

ORD record: ord-870050b383504dd190f27bcb7e63cbc2
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07371739B2

Reaction notes

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