HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-7-ethyl-8-isopropyl-2-[2-methoxy-4-(4-pyrrolidin-1-yl-piperidin-1-yl)-phenylamino]-5-methyl-7,8-dihydro-5H-pteridin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Methoxy-4-(4-(pyrrolidin-1-yl)piperidin-1-yl)aniline | HCID 57416146 | — |
| Reactant | (R)-2-Chloro-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropyrimido[4,5-b]pyrazine | HCID 58405561 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (R)-7-ethyl-8-isopropyl-2-[2-methoxy-4-(4-pyrrolidin-1-yl-piperidin-1-yl)-phenylamino]-5-methyl-7,8-dihydro-5H-pteridin-6-one | HCID 11598647 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
50 mg (0.186 mmol) (R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one are dissolved in 0.5 ml of ethanol and 1 ml distilled water, combined with 136 μl of a 33% aqueous hydrochloric acid and 56 mg (0.203 mmol) 2-methoxy-4-(4-pyrrolidin-1-yl-piperidin-1-yl)-phenylamine (method 1) and stirred for 3 h at 100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371753B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-0b2d8392d56243cea43e020ab8bdce4b |
| Source note | uspto-grants-2008_05 |