反应详情

温度

100 °C

50 mg (0.186 mmol) (R)-2-chloro-7-ethyl-8-isopropyl-5-methyl-7,8-dihydro-5H-pteridin-6-one are dissolved in 0.5 ml of ethanol and 1 ml distilled water, combined with 136 μl of a 33% aqueous hydrochloric acid and 56 mg (0.203 mmol) 2-methoxy-4-(4-pyrrolidin-1-yl-piperidin-1-yl)-phenylamine (method 1) and stirred for 3 h at 100° C.

1. distillation1 ml distilled water