Phenyl chloroformate → HCID 11774849, compound

HRID 2222154Notes

Reaction equation

HRID 2222154 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1.Cl[C:20](OC1C=CC=CC=1)=[O:21].[O:29]1[C:33]2([CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[O:32][CH2:31][CH2:30]1>>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:20]([N:36]3[CH2:37][CH2:38][C:33]4([O:32][CH2:31][CH2:30][O:29]4)[CH2:34][CH2:35]3)=[O:21])[S:11][C:7]=2[C:6]([CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 15891Phenyl chloroformateHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 220157354-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine

Product 1

HCID 11774849HCID 11774849, compound

Procedure

Using 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine, phenyl chloroformate and 1,4-dioxa-8-aza-spiro[4.5]decane, the title compound was prepared as white crystals (53% yield). MS: m/e=434(M+H+), mp 208-209° C.

Sources & evidence

ORD record
ord-fe92be28f6fa48bbadd6f308df006e56
Source dataset
uspto-grants-2008_05
Patent number
US07371748B2

Reaction notes

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