Phenyl chloroformate → HCID 86595141, compound

HRID 2222156Notes

Reaction equation

HRID 2222156 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1.Cl[C:20](OC1C=CC=CC=1)=[O:21].[C@H:29]12[CH2:35][C@H:32]([O:33][CH2:34]1)[CH2:31][NH:30]2>>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:20]([N:30]3[CH2:31][C@@H:32]4[CH2:35][C@H:29]3[CH2:34][O:33]4)=[O:21])[S:11][C:7]=2[C:6]([CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 15891Phenyl chloroformateHCID 11159293(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane hydrobromideHCID 220157354-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine

Product 1

HCID 86595141HCID 86595141, compound

Procedure

Using 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine, phenyl chloroformate and (1S,4S)-2-aza-5-oxabicyclo-[2.2.1]heptane, the title compound was prepared as white crystals (52% yield). MS: m/e=390(M+H+), mp 193-197° C.

Sources & evidence

ORD record
ord-a42505281f70403590b156383d331555
Source dataset
uspto-grants-2008_05
Patent number
US07371748B2

Reaction notes

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