4-Fluoro-3-methylbenzoic acid → N-(7-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-4-fluoro-3-methyl-benzamide

HRID 2222163Notes

Reaction equation

HRID 2222163 reaction equation
[O:1]1[CH2:7][CH:6]([C:8]2[C:16]3[S:15][C:14]([NH2:17])=[N:13][C:12]=3[C:11]([O:18][CH3:19])=[CH:10][CH:9]=2)[CH2:5][O:4][CH2:3][CH2:2]1.[F:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](O)=[O:26])=[CH:23][C:22]=1[CH3:30].O1CC(C2C3SC(NC(C4SC(C)=CC=4)=O)=NC=3C(OC)=CC=2)COCC1>>[O:4]1[CH2:5][CH:6]([C:8]2[C:16]3[S:15][C:14]([NH:17][C:25](=[O:26])[C:24]4[CH:28]=[CH:29][C:21]([F:20])=[C:22]([CH3:30])[CH:23]=4)=[N:13][C:12]=3[C:11]([O:18][CH3:19])=[CH:10][CH:9]=2)[CH2:7][O:1][CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 2428284-Fluoro-3-methylbenzoic acidHCID 113731005-Methyl-thiophene-2-carboxylic acid (7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-amideHCID 597118057-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-ylamine

Product 1

HCID 86595144N-(7-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-4-fluoro-3-methyl-benzamide

Procedure

Using 7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-ylamine and 4-fluoro-3-methyl-benzoic acid, the title compound was prepared in the same manner as described for 5-methyl-thiophene-2-carboxylic acid (7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-amide and obtained as light brown powder. MS: m/e=417(M+H+).

Workup

  1. customobtained as light brown powder

Sources & evidence

ORD record
ord-2e4f2becd4ee476391487e3db8788fff
Source dataset
uspto-grants-2008_05
Patent number
US07371748B2

Reaction notes

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