HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → N-(7-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-4-pyrrolidin-1-ylmethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-Chloromethyl-N-(7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-benzamide | HCID 11750844 | — |
| Reactant | N-(4-methoxy-7-phenyl-benzothiazol-2-yl)-4-pyrrolidin-1-ylmethyl-benzamide | HCID 22283140 | — |
| Product | N-(7-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-4-pyrrolidin-1-ylmethyl-benzamide | HCID 86595145 | — |
Reaction Steps
4-Chloromethyl-N-(7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-benzamide and pyrrolidine were reacted as described for N-(4-methoxy-7-phenyl-benzothiazol-2-yl)-4-pyrrolidin-1-ylmethyl-benzamide in WO01/9786. Usual workup, preparative reversed-phase HPLC and final dry-freezing afforded the title compound as light brown powder. MS: m/e=468(M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371748B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-f422b2ededaf43b194111b4d6bf97668 |
| Source note | uspto-grants-2008_05 |