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HRID2222170

反应详情

EQUATION

反应方程式

HRID 2222170 的结构方程式

REACTANTS

反应物

3
结构：CNCCOC
HCID300977

N-(2-Methoxyethyl)methylamine

C4H11NO

结构：COCCNc1cc(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)ccn1
HCID10288248

未命名化合物

结构：COc1ccc(C2COCCOC2)c2sc(NC(=O)c3ccncc3Br)nc12
HCID86595149

未命名化合物

PRODUCTS

生成物

1
结构：COCCN(C)c1cc(C(=O)Nc2nc3c(OC)ccc(C4COCCOC4)c3s2)ccn1
HCID86595148

未命名化合物

PROCEDURE

实验过程

N-(7-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-bromo-isonicotinamide and N-(2-methoxyethyl)-methylamine were reacted as described for 2-(2-methoxy-ethylamino)-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide in WO03/043636. Usual workup, preparative reversed-phase HPLC and final dry-freezing afforded the title compound as light brown solid. MS: m/e=473(M+H+).

WORKUP

后处理

  1. customUsual workup, preparative reversed-phase HPLC and final dry-freezing