2-(Oxolan-2-yl)acetic acid → HCID 86595154, compound

HRID 2222177Notes

Reaction equation

HRID 2222177 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1.[O:19]1[CH2:23][CH2:22][CH2:21][CH:20]1[CH2:24][C:25](O)=[O:26].COC1C2N=C(NC(=O)CC3CCOCC3)SC=2C(C2CCOCC2)=CC=1>>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:25](=[O:26])[CH2:24][CH:20]3[CH2:21][CH2:22][CH2:23][O:19]3)[S:11][C:7]=2[C:6]([CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 2287262-(Oxolan-2-yl)acetic acidHCID 11257802HCID 11257802, compoundHCID 220157354-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine

Product 1

HCID 86595154HCID 86595154, compound

Procedure

Using 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine and (tetrahydro-furan-2-yl)-acetic acid, the title compound was prepared in the same manner as described for N-[4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-2-(tetrahydro-pyran-4-yl)-acetamide and obtained as white solid (50% yield). Mp 170-174° C., MS: m/e=377(M+H+).

Sources & evidence

ORD record
ord-e09fdb9649a742eb815a3702b02fb18d
Source dataset
uspto-grants-2008_05
Patent number
US07371748B2

Reaction notes

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