Bromopyruvic Acid → HCID 86056614, compound

HRID 2222205Notes

Reaction equation

HRID 2222205 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH2:11])=[S:10])=[CH:4][C:3]=1[O:12][CH3:13].Br[CH2:15][C:16](=O)[C:17]([OH:19])=[O:18]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[S:10][CH:15]=[C:16]([C:17]([OH:19])=[O:18])[N:11]=2)=[CH:4][C:3]=1[O:12][CH3:13]

Participants

4

Reactant 2

HCID 70684Bromopyruvic AcidHCID 86056613N-(4-Chloro-3-methoxyphenyl)thiourea

Product 1

HCID 86056614HCID 86056614, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 7.8 g (36 mmol) 1-(4-chloro-3-methoxyphenyl)-thiourea, and 6.2 g (36 mmol) bromopyruvic acid in 80 ml ethanol was heated to 60° C. for 1 h. The precipitate was filtered off and washed with small portions of cold ethanol to yield after drying 10.0 g (98%) of the title compound as crystalline solid.

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with small portions of cold ethanol
  3. customto yield
  4. dry with materialafter drying 10.0 g (98%) of the title compound as crystalline solid

Sources & evidence

ORD record
ord-320ea0b15fcc427e9786dbe04d53929f
Source dataset
uspto-grants-2008_05
Patent number
US07371751B2

Reaction notes

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