HCID 69287886, compound → HCID 59712030, compound

HRID 2222214Notes

Reaction equation

HRID 2222214 reaction equation
[Cl:1][C:2]1[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:3]=1[C:4]([N:6]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=1)[C:7]1[S:8][C:9]([C:12](O)=[O:13])=[CH:10][N:11]=1)=[O:5]>CCN(CC)CC>[CH2:4]([N:6]([CH2:15][CH3:16])[C:12]([C:9]1[S:8][C:7]([N:6]([C:4](=[O:5])[C:3]2[CH:25]=[CH:26][C:27]([Cl:29])=[CH:28][C:2]=2[Cl:1])[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=2)=[N:11][CH:10]=1)=[O:13])[CH3:3]

Participants

3

Reactant 1

HCID 69287886HCID 69287886, compound

Product 1

HCID 59712030HCID 59712030, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

According to the procedure described fort he synthesis of Example 125 further derivatives have been synthesised from 2-[(2,4-Dichloro-benzoyl)-(3,4-dimethoxy-phenyl)-amino]-thiazole-5-carboxylic acid and various commercially available amines and comprise Examples 126-Example 135 below. In cases of Example 135 additionally 2 eq. NEt3 were added to the reaction mixture as the amine hydochloride was used as starting material.

Workup

  1. customfort he synthesis of Example 125 further derivatives

Sources & evidence

ORD record
ord-2b19572a4598417cb9db1913cd0929fd
Source dataset
uspto-grants-2008_05
Patent number
US07371751B2

Reaction notes

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