Triethylamine → HCID 59712059, compound

HRID 2222215Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([C:17](=[O:26])[C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=2[Cl:25])[C:9]2[S:10][C:11]([C:14](O)=[O:15])=[CH:12][N:13]=2)=[CH:4][CH:3]=1.[CH3:27][CH2:28][N:29](CC)[CH2:30][CH3:31]>>[Cl:25][C:19]1[CH:20]=[C:21]([Cl:24])[CH:22]=[CH:23][C:18]=1[C:17]([N:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[C:9]1[S:10][C:11]([C:14]([N:29]2[CH2:30][CH2:31][CH2:27][CH2:28]2)=[O:15])=[CH:12][N:13]=1)=[O:26]

Participants

Reactant 2

HCID 8471Triethylamine

HCID 69287867HCID 69287867, compound

Product 1

HCID 59712059HCID 59712059, compound

Procedure

According to the procedure described fort he synthesis of Example 136 further derivatives have been synthesised from 2-[(4-Chloro-phenyl)-(2,4-dichloro-benzoyl)-amino]-thiazole-5-carboxylic acid and various commercially available amines and comprise Examples 137-Example 146 below. In cases of Example 143 additionally 2 eq. NEt3 were added to the reaction mixture as the amine hydochloride was used as starting material.

Workup

customfort he synthesis of Example 136 further derivatives

Sources & evidence

ORD record: ord-045e10457e4947d58c3127eeb67e3980
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07371751B2

Reaction notes

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