6-Chloroquinoline-4-carbaldehyde → HCID 68892759, compound

HRID 2222230Notes

Reaction equation

HRID 2222230 reaction equation
[CH:1]1([CH2:4][N:5]2[C:10]([NH:11][NH2:12])=[CH:9][C:8](=[O:13])[NH:7][C:6]2=[O:14])[CH2:3][CH2:2]1.[Cl:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[N:22]=[CH:21][CH:20]=[C:19]2[CH:26]=O>CO>[CH:1]1([CH2:4][N:5]2[C:10]([NH:11][N:12]=[CH:26][C:19]3[C:18]4[C:23](=[CH:24][CH:25]=[C:16]([Cl:15])[CH:17]=4)[N:22]=[CH:21][CH:20]=3)=[CH:9][C:8](=[O:13])[NH:7][C:6]2=[O:14])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 31460316-Chloroquinoline-4-carbaldehydeHCID 17990173HCID 17990173, compound

Product 1

HCID 68892759HCID 68892759, compoundYield 105.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 1-cyclopropylmethyl-6-hydrazinopyrimidine-2,4[1H,3H]dione (5.05 g) in methanol (75 mL) was added 6-chloroquinoline 4-carbaldehyde (5.30 g). After stirring overnight, the reaction was filtered, yielding a yellow solid (10 g).

Workup

  1. filtrationthe reaction was filtered

Sources & evidence

ORD record
ord-aff998c262c049c99813a645d36b5400
Source dataset
uspto-grants-2008_05
Patent number
US07371757B2

Reaction notes

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