Potassium Carbonate → HCID 11718244, compound

HRID 2222278Notes

Reaction equation

HRID 2222278 reaction equation
[NH:1]1[CH2:6][CH:5]=[C:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)[CH2:3][CH2:2]1.Cl[CH2:17][CH2:18][C:19]1[C:24](=[O:25])[N:23]2[CH:26]=[CH:27][CH:28]=[C:29]([CH3:30])[C:22]2=[N:21][C:20]=1[CH3:31].C(=O)([O-])[O-].[K+].[K+]>C(#N)C.O>[NH:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]([C:4]2[CH2:3][CH2:2][N:1]([CH2:17][CH2:18][C:19]3[C:24](=[O:25])[N:23]4[CH:26]=[CH:27][CH:28]=[C:29]([CH3:30])[C:22]4=[N:21][C:20]=3[CH3:31])[CH2:6][CH:5]=2)=[CH:8]1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 27610233-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indoleHCID 12414937HCID 12414937, compound

Product 1

HCID 11718244HCID 11718244, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

A solution of 3-(1,2,3,6-tetrahydropyridin-4-yl)indole (25 g, 0.126 mol), 3-(2-chloroethyl)-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one (33 g, 0.139 mol) and potassium carbonate (17.5 g, 0.127 mol) in acetonitrile (500 ml) and water (100 ml) was heated under reflux for 18 h. After cooling the precipitate was collected and washed with water, isopropyl alcohol and petroleum ether respectively. Yield 38 g (76%) of a pale yellow solid. M.p.: 210-212° C.

Workup

  1. temperatureunder reflux for 18 h
  2. temperatureAfter cooling the precipitate
  3. customwas collected
  4. washwashed with water, isopropyl alcohol and petroleum ether respectively

Sources & evidence

ORD record
ord-e83f979a7eb1495a953b41311e8f7b9b
Source dataset
uspto-grants-2008_05
Patent number
US07371769B2

Reaction notes

Loading…