3,4-Dimethoxybenzeneacetonitrile → HCID 10424924, compound

HRID 2222347Notes

Reaction equation

HRID 2222347 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:10])[CH:9]=1)[CH:5]=O.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[CH2:16][C:17]#[N:18]>>[F:1][C:2]1[CH:3]=[C:4](/[CH:5]=[C:16](/[C:15]2[CH:19]=[CH:20][C:21]([O:22][CH3:23])=[C:13]([O:12][CH3:11])[CH:14]=2)\[C:17]#[N:18])[CH:7]=[C:8]([F:10])[CH:9]=1

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 5881603,5-Difluorobenzaldehyde

Product 1

HCID 10424924HCID 10424924, compoundYield 69.8%

Procedure

3,5-Difluorobenzaldehyde (1.42 g) and 3,4-dimethoxybenzyl cyanide (1.77 g) were subjected to condensation in accordance with process A of (production process 2), to thereby produce the target product (2.10 g, yield: 69%).

Sources & evidence

ORD record
ord-1a8ca7b1a846457aa6476bbe770bc95b
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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