3,4-Dimethoxybenzeneacetonitrile → (z)-2-(3,4-Dimethoxy-phenyl)-3-(2,4,5-trifluoro-phenyl)-acrylonitrile

HRID 2222351Notes

Reaction equation

HRID 2222351 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[CH:6][C:3]=1[CH:4]=O.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH2:17][C:18]#[N:19]>>[CH3:12][O:13][C:14]1[CH:15]=[C:16](/[C:17](=[CH:4]/[C:3]2[CH:6]=[C:7]([F:11])[C:8]([F:10])=[CH:9][C:2]=2[F:1])/[C:18]#[N:19])[CH:20]=[CH:21][C:22]=1[O:23][CH3:24]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 5192782,4,5-Trifluorobenzaldehyde

Product 1

HCID 10358558(z)-2-(3,4-Dimethoxy-phenyl)-3-(2,4,5-trifluoro-phenyl)-acrylonitrileYield 26%

Procedure

2,4,5-Trifluorobenzaldehyde (160 mg) and 3,4-dimethoxybenzyl cyanide (177 mg) were subjected to condensation in accordance with process B of (production process 2), to thereby produce the target product (80 mg, yield: 26%).

Sources & evidence

ORD record
ord-09b3a890437640488b984734f15f6497
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

Loading…