HCID 23089852, compound → HCID 10085056, compound

HRID 2222355Notes

Reaction equation

HRID 2222355 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[C:11](=[CH:14]/[C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=2)/[C:12]#[N:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]>C(O)(=O)C.[Zn]>[NH2:21][C:18]1[CH:19]=[CH:20][C:15](/[CH:14]=[C:11](/[C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)\[C:12]#[N:13])=[CH:16][CH:17]=1

Participants

4

Reactant 1

HCID 23089852HCID 23089852, compound

Product 1

HCID 10085056HCID 10085056, compoundYield 95.6%

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 176Acetic AcidSolvent

Procedure

Compound 19 (880 mg) was dissolved in acetic acid. Zinc powder was added to the resultant solution, and the resultant mixture was stirred for four hours. The mixture was concentrated to dryness under reduced pressure, followed by purification by use of a silica gel column, to thereby produce the target product (760 mg, yield: 95%).

Workup

  1. concentrationThe mixture was concentrated to dryness under reduced pressure
  2. customfollowed by purification by use of a silica gel column

Sources & evidence

ORD record
ord-87fc718adf564676b6c4dc82edbbe678
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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