反应详情

Compound 1 (281 mg) and ethyl chloroacetate (245 mg) were dissolved in acetone, and potassium carbonate was added to the resultant solution, followed by reflux for three hours. The resultant mixture was subjected to filtration, and insoluble matter was removed from the mixture. The resultant filtrate was concentrated to dryness under reduced pressure, followed by recrystallization, to thereby produce the target product (124 mg, yield: 34%).

1. temperatureby reflux for three hours
2. filtrationThe resultant mixture was subjected to filtration, and insoluble matter
3. customwas removed from the mixture
4. concentrationThe resultant filtrate was concentrated to dryness under reduced pressure
5. customfollowed by recrystallization