HCID 9995520, compound → HCID 9995865, compound

HRID 2222372Notes

Reaction equation

HRID 2222372 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[C:11](=[CH:14]/[C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-])=O)[CH:16]=2)/[C:12]#[N:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]>C(O)(=O)C.[Zn]>[NH2:21][C:17]1[CH:16]=[C:15](/[CH:14]=[C:11](/[C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)\[C:12]#[N:13])[CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 1

HCID 9995520HCID 9995520, compound

Product 1

HCID 9995865HCID 9995865, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 176Acetic AcidSolvent

Procedure

Compound 33 (1.80 g) was dissolved in acetic acid. Zinc powder was added to the resultant solution, and the resultant mixture was stirred for four hours. The mixture was concentrated to dryness under reduced pressure, followed by purification by use of a silica gel column, to thereby produce the target product (1.30 g, yield: 80%).

Workup

  1. concentrationThe mixture was concentrated to dryness under reduced pressure
  2. customfollowed by purification by use of a silica gel column

Sources & evidence

ORD record
ord-7b6aef61cc9f49a1bfabc6aa7dc06924
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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