HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-methylindole → 6-Cyano-4-(2-methylindol-5-ylamino)-7-(3-(pyrrolidin-1-yl)propoxy)quinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-methylindole | HCID 2733992 | — |
| Reactant | 4-Chloro-6-cyano-7-(3-(pyrrolidin-1-yl)propoxy)quinoline | HCID 59712234 | — |
| Product | 6-Cyano-4-(2-methylindol-5-ylamino)-7-(3-(pyrrolidin-1-yl)propoxy)quinoline hydrochloride | HCID 69182568 | 39.6% |
Reaction Steps
Using an analogous procedure to that described in Example 33, 4-chloro-6-cyano-7-(3-(pyrrolidin-1-yl)propoxy)quinoline (100 mg), (prepared as described for the starting material in Example 11), was reacted with 5-amino-2-methylindole (51 mg) to give 6-cyano-4-(2-methylindol-5-ylamino)-7-(3-(pyrrolidin-1-yl)propoxy)quinoline hydrochloride (58 mg, 37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371765B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-6123b285a0884ec98d785f1b4a7597a4 |
| Source note | uspto-grants-2008_05 |