反应详情

1.8 g of t-butyl N-(5-formyl-2-methoxybenzyl)carbamate was dissolved in 12 ml of ethanol and 6 ml of tetrahydrofuran, and 0.15 g of sodium borohydride was added. After stirring at room temperature overnight, water was added and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, and the solvent was removed. The residue was purified by silica gel column chromatography, to give 1.65 g of the title compound from the 1:1 hexane-ethyl acetate fraction.

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialThe extract was dried over anhydrous magnesium sulfate
3. customthe solvent was removed
4. customThe residue was purified by silica gel column chromatography