HCID 59712421, compound → HCID 23023483, compound

HRID 2222453Notes

Reaction equation

HRID 2222453 reaction equation
[Si]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([CH:23]=[CH:24][C:25]=1[O:26][CH2:27][CH3:28])[CH2:13][C:14]1([C:19]([O:21][CH3:22])=[O:20])[CH2:18][CH2:17][CH2:16][O:15]1)(C(C)(C)C)(C)C>CO>[CH2:27]([O:26][C:25]1[CH:24]=[CH:23][C:12]([CH2:13][C:14]2([C:19]([O:21][CH3:22])=[O:20])[CH2:18][CH2:17][CH2:16][O:15]2)=[CH:11][C:10]=1[CH2:9][OH:8])[CH3:28]

Participants

3

Reactant 1

HCID 59712421HCID 59712421, compound

Product 1

HCID 23023483HCID 23023483, compoundYield 108.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.409 g of methyl 2-[3-(t-butyldimethylsilanyloxymethyl)-4-ethoxybenzyl]tetrahydro-2-furancarboxylate in 20 ml of methanol was treated with 0.400 g of Dowex 50X ion-exchange resin for 6 hours, then the reaction mixture was filtrated and evaporated. The residue was purified by silica gel column chromatography, to give 0.320 g of the title compound.

Workup

  1. filtrationthe reaction mixture was filtrated
  2. customevaporated
  3. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-55631405d0714ca8a046f508d60f1b47
Source dataset
uspto-grants-2008_05
Patent number
US07371777B2

Reaction notes

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