Trifluoroacetic acid → Ethyl 3-chloro-4-[2-(hydroxycarbonylmethoxy)-1-methyl-ethylamino]-benzoate

HRID 2222558Notes

Reaction equation

HRID 2222558 reaction equation
C([O:5][C:6]([CH2:8][O:9][CH2:10][CH:11]([NH:13][C:14]1[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][C:15]=1[Cl:25])[CH3:12])=[O:7])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:25][C:15]1[CH:16]=[C:17]([CH:23]=[CH:24][C:14]=1[NH:13][CH:11]([CH3:12])[CH2:10][O:9][CH2:8][C:6]([OH:7])=[O:5])[C:18]([O:20][CH2:21][CH3:22])=[O:19]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67049365Ethyl 4-[2-(tert.-butoxycarbonyl-methoxy)-1-methyl-ethylamino]-3-chlorobenzoate

Product 1

HCID 67048486Ethyl 3-chloro-4-[2-(hydroxycarbonylmethoxy)-1-methyl-ethylamino]-benzoate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared analogously to Example 1g from ethyl 4-[2-(tert.-butoxycarbonyl-methoxy)-1-methyl-ethylamino]-3-chloro-benzoate and trifluoroacetic acid in dichloromethane.

Sources & evidence

ORD record
ord-e55342895a8642098143fec2ded20c78
Source dataset
uspto-grants-2008_05
Patent number
US07371743B2

Reaction notes

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