Trifluoroacetic acid → HCID 66972081, compound

HRID 222274Notes

Reaction equation

HRID 222274 reaction equation
[O:1]1[CH2:6][CH2:5][O:4][CH2:3][CH:2]1[CH2:7][N:8]([CH3:20])[S:9]([NH:12]C(=O)OC(C)(C)C)(=[O:11])=[O:10].[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>ClCCl>[F:21][C:22]([F:27])([F:26])[C:23]([O-:25])=[O:24].[O:1]1[CH2:6][CH2:5][O:4][CH2:3][C@H:2]1[CH2:7][N:8]([CH3:20])[S:9]([NH3+:12])(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 76006351Tert-butyl {[(1,4-dioxan-2-ylmethyl)(methyl)amino]sulfonyl}carbamate

Product 1

HCID 66972081HCID 66972081, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl {[(1,4-dioxan-2-ylmethyl)(methyl)amino]sulfonyl}carbamate (1.25 g, 4.03 mmol) was dissolved in 10 mL dichloromethane and 20 mL trifluoroacetic acid and stirred at ambient temperature. After 2 hours, the solution was concentrated and azeotroped twice with heptane to afford the title compound. LRMS (APCI) calc'd for (C6H15N2O4S) [M+H]+, 211.1; found, 211.1.

Workup

  1. concentrationthe solution was concentrated
  2. customazeotroped twice with heptane

Sources & evidence

ORD record
ord-16ef8d8738aa4b7faa75335cc165723d
Source dataset
uspto-grants-2012_06
Patent number
US08207186B2

Reaction notes

Loading…