Water → HCID 59713045, compound

HRID 2222759Notes

Reaction equation

HRID 2222759 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:22]=[CH:21][C:6]([O:7][CH:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)[CH2:9][OH:10])=[CH:5][CH:4]=1.[C:25](Cl)(=[O:28])[CH2:26][CH3:27].O.CCOCC>N1C=CC=CC=1>[F:1][C:2]([F:23])([F:24])[C:3]1[CH:4]=[CH:5][C:6]([O:7][CH:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:18])([F:19])[F:20])[CH:12]=2)[CH2:9][O:10][C:25](=[O:28])[CH2:26][CH3:27])=[CH:21][CH:22]=1

Participants

6

Reactant 4

HCID 962WaterHCID 3283Diethyl EtherHCID 62324Propionyl chlorideHCID 25259878HCID 25259878, compound

Product 1

HCID 59713045HCID 59713045, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
0 °C

Procedure

2-(4-Trifluoromethyl-phenoxy)-2-(3-trifluoromethyl-phenyl)-ethanol, 125, (0.01 mol) was dissolved in pyridine (20 mL) and the solution was cooled to 0° C. Propionyl chloride (0.015 mol) was added. The progress of the reaction was monitored by TLC. When the reaction was complete, water and ether were added. The organic phase was washed with dilute hydrochloric acid, dried and concentrated. The residue was chromatographed to afford the title compound 135.

Workup

  1. washThe organic phase was washed with dilute hydrochloric acid
  2. customdried
  3. concentrationconcentrated
  4. customThe residue was chromatographed

Sources & evidence

ORD record
ord-922b68d8ed34474286cd99165c34cbfd
Source dataset
uspto-grants-2008_05
Patent number
US07371888B2

Reaction notes

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