Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Propionyl chloride | HCID 62324 | — |
| Reactant | HCID 25259878 | HCID 25259878 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 59713045 | HCID 59713045 | — |
Reaction Steps
2-(4-Trifluoromethyl-phenoxy)-2-(3-trifluoromethyl-phenyl)-ethanol, 125, (0.01 mol) was dissolved in pyridine (20 mL) and the solution was cooled to 0° C. Propionyl chloride (0.015 mol) was added. The progress of the reaction was monitored by TLC. When the reaction was complete, water and ether were added. The organic phase was washed with dilute hydrochloric acid, dried and concentrated. The residue was chromatographed to afford the title compound 135.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07371888B2 |
|---|
| Source dataset | uspto-grants-2008_05 |
|---|
| ORD ID | ord-922b68d8ed34474286cd99165c34cbfd |
|---|
| Source note | uspto-grants-2008_05 |
|---|
