Sodium Hydroxide → HCID 59713023, compound

HRID 2222762Notes

Reaction equation

HRID 2222762 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:23]=[CH:22][C:6]([O:7][CH:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1.[OH-].[Na+:27]>CCOC(C)=O>[Na+:27].[F:1][C:2]([F:24])([F:25])[C:3]1[CH:4]=[CH:5][C:6]([O:7][CH:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:19])([F:20])[F:21])[CH:13]=2)[C:9]([O-:11])=[O:10])=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11210718HCID 11210718, compound

Product 1

HCID 59713023HCID 59713023, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of the acid 39 in EtOAc was treated with 1 eq. of 1N NaOH, and the resultant product was recrystallized from EtOAc/hexanes to afford white solid Na salt 141.

Workup

  1. customthe resultant product was recrystallized from EtOAc/hexanes
  2. customto afford white solid Na salt 141

Sources & evidence

ORD record
ord-76cb0a2fd28f41bc99fec0bbdeac1e89
Source dataset
uspto-grants-2008_05
Patent number
US07371888B2

Reaction notes

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