1-Bromo-3-methoxypropane → HCID 68799377, compound

HRID 2222954Notes

Reaction equation

HRID 2222954 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][O:23][CH3:24])=[CH:15][CH:14]=1)[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(NC(C1C=CC(OCCN2CCCC2)=CC=1)C(O)=O)=O)(C)(C)C.BrCCCOC>>[C:1]([O:5][C:6]([NH:8][C@H:9]([C:13]1[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH2:21][CH2:22][O:23][CH3:24])=[CH:17][CH:18]=1)[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 5245511-Bromo-3-methoxypropaneHCID 68797985HCID 68797985, compoundHCID 68799558HCID 68799558, compound

Product 1

HCID 68799377HCID 68799377, compound

Procedure

Prepared as described in example 3 except that tert-butoxycarbonylamino-[4-(3-methoxy-propoxy)-phenyl]-acetic acid was used in place of tert-butoxycarbonylamino-(3-fluoro-4-methoxy-phenyl)-acetic acid in step 7. (R)-tert-Butoxycarbonylamino-[4-(3-methoxy-propoxy)-phenyl]-acetic acid was prepared in a manner similar to that described for the preparation of tert-butoxycarbonylamino-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-acetic acid in example 4 (o) except that 1-bromo-3-methoxy-propane was used in place of chloroethylpyrrolidine hydrochloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7e793e00f93f4d70b915f3e5fa4d5ca5
Source dataset
uspto-grants-2008_05
Patent number
US07371869B2

Reaction notes

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