(2R)-2-{[(tert-butoxy)carbonyl]amino}-2-phenylacetic acid → 2-((S)-2-Amino-3-thiazol-2-yl-propionylamino)-thiazole-4-carboxylic acid methyl ester

HRID 2222963노트

반응식

HRID 2222963 반응식
[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]([NH:10][C:11](=[O:20])[CH:12]([NH2:19])[CH2:13][C:14]2[S:15][CH:16]=[CH:17][N:18]=2)[S:8][CH:9]=1)=[O:4].C(OC(N[C@H](C1C=CC=CC=1)C(O)=O)=O)(C)(C)C.COC(C1N=C(NC(=O)[C@@H](N)CC2C=CC=CC=2)SC=1)=O.C(OC(N[C@@H](CC1SC=CN=1)C(O)=O)=O)(C)(C)C>>[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]([NH:10][C:11](=[O:20])[C@@H:12]([NH2:19])[CH2:13][C:14]2[S:15][CH:16]=[CH:17][N:18]=2)[S:8][CH:9]=1)=[O:4]

참가 물질

5

반응물 4

HCID 2755953(2R)-2-{[(tert-butoxy)carbonyl]amino}-2-phenylacetic acidHCID 11184857(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(1,3-thiazol-2-yl)propanoic acidHCID 866040402-((S)-2-amino-3-phenyl-propionylamino)-thiazole-4-carboxylic acid methyl esterHCID 866040482-(2-Amino-3-thiazol-2-yl-propionylamino)-thiazole-4-carboxylic acid methyl ester

생성물 1

HCID 866040472-((S)-2-Amino-3-thiazol-2-yl-propionylamino)-thiazole-4-carboxylic acid methyl ester

실험 절차

Prepared as described in example 10 except that (R)—N-(tert-butyloxycarbonyl)-4-methyoxyphenylglycine and 2-(2-amino-3-thiazol-2-yl-propionylamino)-thiazole-4-carboxylic acid methyl ester were used in place of (R)-tert-butoxycarbonylamino-phenylacetic acid and 2-((S)-2-amino-3-phenyl-propionylamino)-thiazole-4-carboxylic acid methyl ester respectively in step 1. 2-((S)-2-Amino-3-thiazol-2-yl-propionylamino)-thiazole-4-carboxylic acid methyl ester was prepared as described in example 3 except that (S)-2-tert-butoxycarbonylamino-3-thiazol-2-yl-propionic acid was used in place of (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid in step 3.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-3daef1cc5c5c41599a114ae5e1fe12f3
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07371869B2

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