(2R)-2-{[(tert-butoxy)carbonyl]amino}-2-phenylacetic acid → 2-((S)-2-Amino-3-thiazol-2-yl-propionylamino)-thiazole-4-carboxylic acid methyl ester

Participants

Reaction Steps

Prepared as described in example 10 except that (R)—N-(tert-butyloxycarbonyl)-4-methyoxyphenylglycine and 2-(2-amino-3-thiazol-2-yl-propionylamino)-thiazole-4-carboxylic acid methyl ester were used in place of (R)-tert-butoxycarbonylamino-phenylacetic acid and 2-((S)-2-amino-3-phenyl-propionylamino)-thiazole-4-carboxylic acid methyl ester respectively in step 1. 2-((S)-2-Amino-3-thiazol-2-yl-propionylamino)-thiazole-4-carboxylic acid methyl ester was prepared as described in example 3 except that (S)-2-tert-butoxycarbonylamino-3-thiazol-2-yl-propionic acid was used in place of (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid in step 3.

Provenance & Evidence