反应详情

A solution of 2-amino-thiazole-4-carboxylic acid ethyl ester (258 mg, 1.5 mmol) (prepared as described in example 3, step 1) in concentrated aqueous ammonium hydroxide was heated to reflux for 8 hours. The reaction mixture was concentrated to dryness and residual water removed by azeotropic distillation with toluene. The residue was purified by chromatography over silica gel eluted with 2% v/v methanol in ethyl acetate to give 2-amino-thiazole-4-carboxylic acid amide as a colorless solid (149 mg, 69%).

1. temperatureto reflux for 8 hours
2. concentrationThe reaction mixture was concentrated to dryness and residual water
3. customremoved by azeotropic distillation with toluene
4. customThe residue was purified by chromatography over silica gel
5. washeluted with 2% v/v methanol in ethyl acetate