反应详情

温度

0 °C

To a stirred solution of (4-dimethylcarbamoyl-thiazol-2-yl)-carbamic acid tert-butyl ester (150 mg, 0.53 mmol) in dichloromethane (1 mL) at 0° C. was added trifluoroacetic acid (2.5 mL, 32 mmol) and the mixture stirred at 0° C. until all of the starting material had been consumed. The reaction mixture was concentrated in vacuo, the residue dissolved in ethyl acetate, washed with saturated aqueous sodium bicarbonate (2×), brine, dried over sodium sulfate and concentrated in vacuo to give crude 2-amino-thiazole-4-carboxylic acid dimethylamide as a viscous colorless oil which was used without further purification (85 mg, 90%).

1. customhad been consumed
2. concentrationThe reaction mixture was concentrated in vacuo
3. dissolutionthe residue dissolved in ethyl acetate
4. washwashed with saturated aqueous sodium bicarbonate (2×), brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo