Glycine → lysylglycine

HRID 2223026Notes

Reaction equation

HRID 2223026 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:15]([O:17]N1C(=O)CCC1=O)=O)[CH2:3][CH2:4][CH2:5][CH2:6][NH:7]C(OC(C)(C)C)=O.[NH2:32][CH2:33][C:34]([OH:36])=[O:35]>>[CH2:4]([CH2:3][C@H:2]([NH2:1])[C:15]([NH:32][CH2:33][C:34]([OH:36])=[O:35])=[O:17])[CH2:5][CH2:6][NH2:7]

Participants

3

Reactant 2

HCID 750Glycine2×HCID 138755342,5-Dioxopyrrolidin-1-yl N~2~,N~6~-bis(tert-butoxycarbonyl)-L-lysinate

Product 1

HCID 7022320lysylglycine

Procedure

Lys-Gly-Amp was synthesized by a similar method except the amino acid starting material was Boc-Lys(Boc)-OSu and the starting drug conjugate was Gly-Amp (see Gly-Amp synthesis).

Sources & evidence

ORD record
ord-fa47e09f15c04993b12e41a749d2bc73
Source dataset
uspto-grants-2008_05
Patent number
US07375083B2

Reaction notes

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