Hydrocarbostyril → HCID 13174712, compound

HRID 2223107Notes

Reaction equation

HRID 2223107 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]1=[O:11].Cl[CH2:13][CH2:14][C:15]([N:18]=CC1C=CC=CC=1)([CH3:17])[CH3:16]>>[NH2:18][C:15]([CH3:17])([CH3:16])[CH2:14][CH2:13][N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]1=[O:11]

Participants

3

Reactant 2

HCID 64796HydrocarbostyrilHCID 13393267HCID 13393267, compound

Product 1

HCID 13174712HCID 13174712, compound

Procedure

Prepared analogously to the method described for Example 6a) from 15.7 g (107 mmol) of 3,4-dihydroquinolin-2-one and 24.9 g (119 mmol) of (3-chloro-1,1-dimethylpropyl)-(1-phenylmethylidene)amine. Unlike in the method mentioned above, the product is precipitated not as the maleate but as the hydrochloride. Yield: 6.9 g (24%, hydrochloride); melting range: 200° C.-203° C.

Workup

  1. customPrepared analogously to the method
  2. customis precipitated not as the maleate but as the hydrochloride

Sources & evidence

ORD record
ord-99984d078bd84b06863737f6beabb730
Source dataset
uspto-grants-2008_05
Patent number
US07375104B2

Reaction notes

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