反应详情

温度

80 °C

100 g of molecular sieve (4 Å), tris(dibenzylideneacetone)dipalladium (5.88 g, 6.42 mmol), tri-tert-butylphosphonium-tetrafluoroborate (3.50 g, 12.06 mmol), dicyclohexylmethylamine (81.2 mL, 0.371 mol), dried tetrabutylammonium iodide (105.8 g, 0.286 mol), and methyl acrylate (32.6 mL, 0.362 mol) are added to a solution of 2-acetyl-4-benzyloxy-6-nitrophenyl trifluoromethanesulfonate (100.0 g, 0.238 mol) in dioxane (360 mL) under a nitrogen atmosphere. The reaction mixture is stirred for 2 hours at 80° C., diluted with ether (2 L) and combined with 500 g silica gel. The suspension is stirred for 10 minutes, filtered, and the silica gel is washed several times with ether (4×600 mL). The combined organic phases are washed with 1 M aqueous hydrochloric acid (300 mL), sodium bicarbonate solution, and sodium chloride solution, dried with sodium sulfate, and evaporated down. The oily crude product is recrystallized from hot ethanol (0.75 L). The precipitate is filtered off, washed with ethanol (2×50 mL) and dried at 40° C. Yield: 32.2 g (38%); mass spectroscopy: [M+H]+=356.

1. stirringThe suspension is stirred for 10 minutes
2. filtrationfiltered
3. washthe silica gel is washed several times with ether (4×600 mL)
4. washThe combined organic phases are washed with 1 M aqueous hydrochloric acid (300 mL), sodium bicarbonate solution, and sodium chloride solution
5. dry with materialdried with sodium sulfate
6. customevaporated down
7. customThe oily crude product is recrystallized from hot ethanol (0.75 L)
8. filtrationThe precipitate is filtered off
9. washwashed with ethanol (2×50 mL)
10. customdried at 40° C