Dichloromethane → HCID 58617365, compound

HRID 2223156Notes

Reaction equation

HRID 2223156 reaction equation
[CH3:1][C:2]1([CH3:14])[CH2:7][C:6](N2CCOCC2)=[CH:5][CH2:4][CH2:3]1.CC1(C)CCCC(N2CC[O:25]CC2)=C1.[CH2:29]([O:31][C:32]1[CH:37]=[CH:36][C:35]([N:38]=[C:39]=[O:40])=[CH:34][CH:33]=1)[CH3:30].ClCCl>C(Cl)(Cl)Cl>[CH2:29]([O:31][C:32]1[CH:37]=[CH:36][C:35]([NH:38][C:39]([CH:5]2[CH2:4][CH2:3][C:2]([CH3:14])([CH3:1])[CH2:7][C:6]2=[O:25])=[O:40])=[CH:34][CH:33]=1)[CH3:30]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 122887Benzene, 1-ethoxy-4-isocyanato-HCID 86604109HCID 86604109, compound

Product 1

HCID 58617365HCID 58617365, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Compound I1, a mixture of 4-(5,5-dimethyl-cyclohex-1-enyl)-morpholine/4-(3,3-Dimethyl-cyclohex-1-enyl)-morpholine (3:1), (1.28 g, 6.55 mmol.) and 4-ethoxyphenyl isocyanate (1.20 g, 7.20 mmol.) in 32 mL of chloroform was stirred at room temperature for 20 h. Upon completion, 50 mL of dichloromethane was added and the resulting solution was washed with water twice and brine, dried over anhydrous sodium sulfate and concentrated. There was obtained 2.04 g of I2, which was used in next step without purification. MS (ESI+) 290 [M+H]+.

Workup

  1. washthe resulting solution was washed with water twice
  2. dry with materialbrine, dried over anhydrous sodium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-7cc367683d25429f9f621039bed823a2
Source dataset
uspto-grants-2008_05
Patent number
US07375102B2

Reaction notes

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