HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 6-benzyloxy-5-nitro-indole-2-carboxylate → Methyl 5-amino-6-hydroxy-indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 6-benzyloxy-5-nitro-indole-2-carboxylate | HCID 16110225 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 5-amino-6-hydroxy-indole-2-carboxylate | HCID 22350178 | — |
Reaction Steps
A mixture of 0.67 g (2.0 mmol) of methyl 6-benzyloxy-5-nitro-indole-2-carboxylate, 60 ml of tetrahydrofuran and 0.1 g of 10% Pd/C catalyst is hydrogenated for 5 h. The catalyst is filtered off and the filtrate containing the title compound is used immediately in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07375116B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-ebc43dd9e2074b09b87f978ea8d23977 |
| Source note | uspto-grants-2008_05 |