反应详情

To a solution of 4.0 g (14.75 mmol) N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid ethyl ester in 300 ml of ethanol, 15 ml of water and 1.41 g (59 mmol) of lithium hydroxide were added and the mixture was refluxed for 5 hours. After concentration in vacuo water (50 ml) was added and the mixture was extracted with dichloromethane (three times 30 ml). The aqueous phase was acidified with 8 N hydrochloric acid and extracted with dichloromethane (four times 30 ml).

1. temperaturethe mixture was refluxed for 5 hours
2. concentrationAfter concentration in vacuo water (50 ml)
3. additionwas added
4. extractionthe mixture was extracted with dichloromethane (three times 30 ml)
5. extractionextracted with dichloromethane (four times 30 ml)