Diethyl allylmalonate → N-(3,5-Difluoro-benzyl)-2-allyl-malonamic acid

HRID 2223256Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6][C:7](=[O:13])[CH:8]([CH3:12])[C:9]([OH:11])=[O:10].[CH2:18](C(C(OCC)=O)C(OCC)=O)[CH:19]=C>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6][C:7](=[O:13])[CH:8]([CH2:12][CH:18]=[CH2:19])[C:9]([OH:11])=[O:10]

Participants

Reactant 2

HCID 74900Diethyl allylmalonate

HCID 21091473N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid

Product 1

HCID 69280080N-(3,5-Difluoro-benzyl)-2-allyl-malonamic acid

Procedure

N-(3,5-Difluoro-benzyl)-2-allyl-malonamic acid was prepared in analogy to N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid (example 1) from diethyl allyl-malonate.

Sources & evidence

ORD record: ord-d07ec1d66af3435da725d2c7c06400c6
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07375099B2

Reaction notes

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