Diethyl 2-fluoro-2-methylmalonate → N-(3,5-Difluoro-benzyl)-2-fluoro-2-methyl-malonamic acid

HRID 2223257Notes

Reaction equation

HRID 2223257 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6][C:7](=[O:13])[CH:8]([CH3:12])[C:9]([OH:11])=[O:10].[F:18]C(C)(C(OCC)=O)C(OCC)=O>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([F:17])[CH:16]=1)[CH2:5][NH:6][C:7](=[O:13])[C:8]([F:18])([CH3:12])[C:9]([OH:11])=[O:10]

Participants

3

Reactant 2

HCID 13061046Diethyl 2-fluoro-2-methylmalonateHCID 21091473N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid

Product 1

HCID 69280651N-(3,5-Difluoro-benzyl)-2-fluoro-2-methyl-malonamic acid

Procedure

N-(3,5-Difluoro-benzyl)-2-fluoro-2-methyl-malonamic acid was prepared in analogy to N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid (example 1) from diethyl 2-fluoro-2-methyl-malonate.

Sources & evidence

ORD record
ord-22b0aaf6ab004299a91548b8d44a6423
Source dataset
uspto-grants-2008_05
Patent number
US07375099B2

Reaction notes

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