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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2223257Generated: October 27, 2026

Diethyl 2-fluoro-2-methylmalonate → N-(3,5-Difluoro-benzyl)-2-fluoro-2-methyl-malonamic acid

https://huagongshe.com/reaction/2223257

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl 2-fluoro-2-methylmalonateHCID 13061046—
ReactantN-(3,5-difluoro-benzyl)-2-methyl-malonamic acidHCID 21091473—
ProductN-(3,5-Difluoro-benzyl)-2-fluoro-2-methyl-malonamic acidHCID 69280651—

Reaction Steps

N-(3,5-Difluoro-benzyl)-2-fluoro-2-methyl-malonamic acid was prepared in analogy to N-(3,5-difluoro-benzyl)-2-methyl-malonamic acid (example 1) from diethyl 2-fluoro-2-methyl-malonate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07375099B2
Source datasetuspto-grants-2008_05
ORD IDord-22b0aaf6ab004299a91548b8d44a6423
Source noteuspto-grants-2008_05